Bolsa de Investigação (M/F)
Many neurodegenerative diseases are associated with misfolding, aggregation and deposition of proteins such as alpha-synuclein, amyloid beta, and polyglutamine- containing proteins. The deposition of misfolded proteins resulting from aberrant protein- protein interactions results in the malfunctioning of a selected set of neurons. Modulating misfolding and aggregation of the proteins that form these deposits has emerged as a major therapeutic strategy for disease treatment. The main goal of the project is the structural and functional characterization of ataxin-3, the protein associated with Machado-Joseph disease. The successful candidate will be involved in the expression and purification of recombinant ataxin-3 and ataxin-3 interacting proteins for functional and structural studies.
